Projects MVP

MVP expanded to >850k participants with diverse ancestry representation including substantial African American, Hispanic, and Asian cohorts. Large-scale cross-ancestry GWAS meta-analyses with FinnGen and UK Biobank across cardiovascular, metabolic, psychiatric, and aging-related traits. Demonstrated generalizability and ancestry-specific effects of genetic associations.

Expanded disease-specific GWAS across hundreds of traits leveraging the deep EHR phenotyping in the VA system. Whole-genome sequencing of a subset of participants for comprehensive variant discovery. MVP data contributed to multi-biobank meta-analyses with FinnGen and UK Biobank spanning thousands of phenotypes.

Genome-wide genotyping of MVP participants using a custom MVP 1.0 array. Initial GWAS across key phenotypes including coronary artery disease, type 2 diabetes, and PTSD demonstrated the unique value of the veteran cohort for genetic discovery.

Whole-exome sequencing of MVP participants enabling rare variant association studies. Major pharmacogenomics initiatives leveraging the extensive VA medication records to discover genetic determinants of drug response and adverse reactions across diverse ancestries.

Million Veteran Program launched by the US Department of Veterans Affairs as a national research program to study how genes, lifestyle, and military exposures affect health and disease. Aims to enroll over one million US veterans, creating one of the world's largest and most diverse biobanks with rich EHR data.