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Projects CKB

Curation of CKB — listings under the Projects tab.

Summary Table

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NAME STAGE_PERIOD URL
CKB — Baseline recruitment of 0.5 million 2004–2008 https://www.ckbiobank.org/
CKB — Survey methods, baseline & follow-up design 2011 https://www.ckbiobank.org/
CKB — Alcohol and vascular disease (ALDH2 MR) 2019 https://www.ckbiobank.org/
CKB — Lung cancer GWAS & polygenic risk score 2019 https://www.ckbiobank.org/
CKB — Lifestyle, cardiometabolic disease & multimorbidity 2021 https://www.ckbiobank.org/
CKB — Haplotype-resolved reference panel (WGS) 2023 https://www.ckbiobank.org/

Genomics

CKB — Lung cancer GWAS & polygenic risk score

GWAS PRS Lung Cancer
PUBMED_LINK
31326317
STAGE_PERIOD
2019
DESCRIPTION
Large-scale GWAS of lung cancer in Chinese populations identifying novel risk loci, plus development of a polygenic risk score for lung cancer risk stratification in the CKB prospective cohort.
URL
https://www.ckbiobank.org/
TITLE
Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese

CKB — Haplotype-resolved reference panel (WGS)

Reference Panel Imputation Haplotype WGS
PUBMED_LINK
37870428
STAGE_PERIOD
2023
DESCRIPTION
High-resolution haplotype-resolved reference panel from ~5,000 CKB whole-genome sequences. One of the most comprehensive East Asian imputation references for improved GWAS fine-mapping.
URL
https://www.ckbiobank.org/
TITLE
A high-resolution haplotype-resolved Reference panel constructed from the China Kadoorie Biobank Study

Phenotypes & Exposures

CKB — Alcohol and vascular disease (ALDH2 MR)

Alcohol Vascular MR ALDH2
PUBMED_LINK
30955975
STAGE_PERIOD
2019
DESCRIPTION
Conventional and genetic evidence on alcohol and vascular disease in 500,000 Chinese adults. Used ALDH2 Mendelian randomization to demonstrate moderate alcohol does not protect against stroke, challenging the J-shaped curve hypothesis.
URL
https://www.ckbiobank.org/
TITLE
Conventional and genetic evidence on alcohol and vascular disease aetiology: a prospective study of 500,000 men and women in China

CKB — Lifestyle, cardiometabolic disease & multimorbidity

Lifestyle Multimorbidity Cardiometabolic
PUBMED_LINK
34333624
STAGE_PERIOD
2021
DESCRIPTION
Prospective analysis of lifestyle factors (smoking, alcohol, diet, physical activity) and their association with cardiometabolic disease and multimorbidity in Chinese adults.
URL
https://www.ckbiobank.org/
TITLE
Lifestyle, cardiometabolic disease, and multimorbidity in a prospective Chinese study

Study Design & Enrollment

CKB — Baseline recruitment of 0.5 million

Recruitment Baseline Chinese
STAGE_PERIOD
2004–2008
DESCRIPTION
Baseline recruitment of ~512,000 adults aged 30–79 from 10 geographically defined regions across China. Collected questionnaire data, physical measurements, and blood samples with long-term storage.
URL
https://www.ckbiobank.org/

CKB — Survey methods, baseline & follow-up design

Design Cohort Protocol
PUBMED_LINK
22158673
STAGE_PERIOD
2011
DESCRIPTION
Flagship design paper describing CKB: survey methods, baseline characteristics, assay protocols, and long-term follow-up through disease registries and health insurance databases.
URL
https://www.ckbiobank.org/
TITLE
China Kadoorie Biobank of 0.5 million people: survey methods, baseline characteristics and long-term follow-up