Projects Roadmap Epigenomics

The NIH Roadmap Epigenomics Mapping Consortium launched as a public resource of human epigenomic data. Goals included producing a reference set of histone modification, DNA accessibility, DNA methylation, and RNA expression maps across a broad range of human cell types and tissues.

Detailed description of the NIH Roadmap Epigenomics Mapping Consortium, its goals, experimental strategies, data pipeline, and the production of reference epigenomes across diverse human cell types and tissues.

Flagship Roadmap Epigenomics paper: integrative analysis of 111 reference human epigenomes from diverse cell types and tissues. Generated comprehensive maps of histone modifications, chromatin accessibility, DNA methylation, and RNA expression. Defined 15-chromatin-state models (ChromHMM) for each epigenome and developed the Epigenome Roadmap web portal. A foundational resource for understanding gene regulation in human health and disease.