Projects All of Us

Comprehensive overview of All of Us data quality and diversity after enrollment of 315,000+ participants. Demonstrated the program's success in recruiting a diverse cohort (including 83% from historically underrepresented groups) and described the Researcher Workbench cloud platform.

Perspective on how the All of Us Research Program enhances diversity in US biomedical research, highlighting community engagement strategies, participant-centric approaches, and the importance of building trust with historically underrepresented communities.

Landmark genomic data release of whole-genome sequences (WGS), whole-exome sequences (WES), and genotyping array data from over 245,000 diverse participants. Demonstrated 2.1× increase in discovery power for rare variants by including diverse populations. Data accessible via the Researcher Workbench.

Population-scale long-read whole-genome sequencing in the All of Us cohort, enabling comprehensive detection of structural variants, repeat expansions, and complex genomic regions not accessible with short-read sequencing.

President Obama announced the Precision Medicine Initiative, proposing the creation of a national research cohort of one million or more Americans to advance precision medicine.

All of Us Research Program beta launch with soft enrollment. National enrollment officially opened to the public, collecting EHR, surveys, physical measurements, and biospecimens from participants across the US.

Flagship protocol paper describing the All of Us Research Program design, enrollment targets of one million participants, core data collection (EHR, surveys, biospecimens, genomics), and the Researcher Workbench data platform.

Development and validation of the All of Us baseline surveys covering demographics, lifestyle, overall health, healthcare access, and physical activity. Surveys designed for broad accessibility including low-literacy populations.

Transformation of i2b2-sourced electronic health record data into the OMOP Common Data Model for the All of Us Research Program, enabling standardized cross-institutional analysis of clinical data.

Association of step counts over time with chronic disease risk in All of Us participants using Fitbit wearable device data linked to EHR outcomes. Demonstrated that higher step counts were associated with lower risk of multiple chronic conditions.

Long-term sleep monitoring via commercial wearable devices linked to chronic disease outcomes in the All of Us cohort, revealing associations between sleep patterns (duration, consistency, timing) and multiple chronic diseases.