Array

Landmark genomic data release of whole-genome sequences (WGS), whole-exome sequences (WES), and genotyping array data from over 245,000 diverse participants. Demonstrated 2.1× increase in discovery power for rare variants by including diverse populations. Data accessible via the Researcher Workbench.

Genome-wide genotyping using Japanese-specific SNP arrays (Japonica Array v1/v2) designed to capture East Asian-specific variation. Included ~650,000 SNPs with enriched coverage of Japanese population variants.

Genome-wide genotyping of MVP participants using a custom MVP 1.0 array. Initial GWAS across key phenotypes including coronary artery disease, type 2 diabetes, and PTSD demonstrated the unique value of the veteran cohort for genetic discovery.

Genome-wide array genotyping using UK BiLEVE Axiom and UK Biobank Axiom arrays. First 150k participants released in 2015, remainder (full ~500k) released in July 2017.

fastGWA mixed-model association analysis of 2,173 UKB imputed traits, providing a resource-efficient tool for biobank-scale GWAS.

SAIGE method for efficient case-control imbalance control applied to UKB GWAS of >1,400 binary traits.