Diversity

Comprehensive overview of All of Us data quality and diversity after enrollment of 315,000+ participants. Demonstrated the program's success in recruiting a diverse cohort (including 83% from historically underrepresented groups) and described the Researcher Workbench cloud platform.

Perspective on how the All of Us Research Program enhances diversity in US biomedical research, highlighting community engagement strategies, participant-centric approaches, and the importance of building trust with historically underrepresented communities.

gnomAD v4 dramatically expanded to 807,098 exomes and 76,215 genomes, with substantially improved ancestral diversity. v4 included >30 genetic ancestry groups, enabling more precise population-specific allele frequency estimates. New constraint metrics across diverse ancestries and improved structural variant calls made this the most comprehensive human variation resource ever created.