Genome

Rebranded to Genome Aggregation Database (gnomAD) with broadened scope. gnomAD v2.1 released 125,748 exomes and 15,708 genomes — a massive expansion over ExAC. Introduced population-specific allele frequency data across multiple ancestral groups and provided the most comprehensive catalog of human genetic variation to date.

gnomAD v4 dramatically expanded to 807,098 exomes and 76,215 genomes, with substantially improved ancestral diversity. v4 included >30 genetic ancestry groups, enabling more precise population-specific allele frequency estimates. New constraint metrics across diverse ancestries and improved structural variant calls made this the most comprehensive human variation resource ever created.