Meta-analysis

R8–R12 data freezes with progressive sample size increases and phenotype expansion. Cross-biobank meta-analyses with UK Biobank (R10-UKBB, R12-UKBB meta) and later integration with Kanta electronic health record laboratory values, enabling large-scale genetic discovery across populations.

MVP expanded to >850k participants with diverse ancestry representation including substantial African American, Hispanic, and Asian cohorts. Large-scale cross-ancestry GWAS meta-analyses with FinnGen and UK Biobank across cardiovascular, metabolic, psychiatric, and aging-related traits. Demonstrated generalizability and ancestry-specific effects of genetic associations.