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Epigenetics

Summary Table

NAME CATEGORY CITATION YEAR
ROADMAP ROADMAP Roadmap Epigenomics Consortium, Kundaje A, Meuleman W, Ernst J, ...&, Kellis M. (2015) Integrative analysis of 111 reference human epigenomes Nature, 518 (7539) 317-330. doi:10.1038/nature14248. PMID 25693563 2015
ROADMAP ROADMAP Bernstein BE, Stamatoyannopoulos JA, Costello JF, Ren B, ...&, Thomson JA. (2010) The NIH Roadmap Epigenomics Mapping Consortium Nat. Biotechnol., 28 (10) 1045-1048. doi:10.1038/nbt1010-1045. PMID 20944595 2010

ROADMAP

ROADMAP

  • NAME : ROADMAP
  • URL : https://maayanlab.cloud/Harmonizome/resource/Roadmap+Epigenomics ,https://egg2.wustl.edu/roadmap/web_portal/chr_state_learning.html#core_15state
  • TITLE : Integrative analysis of 111 reference human epigenomes
  • DOI : 10.1038/nature14248
  • ABSTRACT : The reference human genome sequence set the stage for studies of genetic variation and its association with human disease, but epigenomic studies lack a similar reference. To address this need, the NIH Roadmap Epigenomics Consortium generated the largest collection so far of human epigenomes for primary cells and tissues. Here we describe the integrative analysis of 111 reference human epigenomes generated as part of the programme, profiled for histone modification patterns, DNA accessibility, DNA methylation and RNA expression. We establish global maps of regulatory elements, define regulatory modules of coordinated activity, and their likely activators and repressors. We show that disease- and trait-associated genetic variants are enriched in tissue-specific epigenomic marks, revealing biologically relevant cell types for diverse human traits, and providing a resource for interpreting the molecular basis of human disease. Our results demonstrate the central role of epigenomic information for understanding gene regulation, cellular differentiation and human disease.
  • COPYRIGHT : https://creativecommons.org/licenses/by-nc-sa/3.0/
  • CITATION : Roadmap Epigenomics Consortium, Kundaje A, Meuleman W, Ernst J, ...&, Kellis M. (2015) Integrative analysis of 111 reference human epigenomes Nature, 518 (7539) 317-330. doi:10.1038/nature14248. PMID 25693563
  • JOURNAL_INFO : Nature ; Nature ; 2015 ; 518 ; 7539 ; 317-330
  • PUBMED_LINK : 25693563

ROADMAP

  • NAME : ROADMAP
  • TITLE : The NIH Roadmap Epigenomics Mapping Consortium
  • DOI : 10.1038/nbt1010-1045
  • ABSTRACT : The NIH Roadmap Epigenomics Mapping Consortium aims to produce a public resource of epigenomic maps for stem cells and primary ex vivo tissues selected to represent the normal counterparts of tissues and organ systems frequently involved in human disease.
  • CITATION : Bernstein BE, Stamatoyannopoulos JA, Costello JF, Ren B, ...&, Thomson JA. (2010) The NIH Roadmap Epigenomics Mapping Consortium Nat. Biotechnol., 28 (10) 1045-1048. doi:10.1038/nbt1010-1045. PMID 20944595
  • JOURNAL_INFO : Nature biotechnology ; Nat. Biotechnol. ; 2010 ; 28 ; 10 ; 1045-1048
  • PUBMED_LINK : 20944595