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Fine-mapping

Catalog entries using this tag (links open the entry card on its page):

Entries

TOPMed — Flagship publications & cross-trait analyses

GWAS Rare Variant Fine-mapping Blood Pressure Lipids
STAGE_PERIOD
2020–2022
DESCRIPTION
Series of landmark papers from TOPMed studies spanning blood pressure, lipid, pulmonary function, and glycemic trait GWAS leveraging the unique WGS data for rare variant association testing. Demonstrated value of deep WGS in diverse populations for fine-mapping and identifying causal variants. Multi-ancestry meta-analyses improved fine-mapping resolution at loci with divergent LD patterns.
URL
https://topmed.nhlbi.nih.gov/