Sumstats Family GWAS
Curation of Family GWAS — listings under the Summary statistics tab.
Summary Table
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| NAME | CATEGORY | URL | MAIN ANCESTRY |
|---|---|---|---|
| UK Biobank family-based GWAS (Guan et al.) | Direct genetic effects | https://www.nature.com/articles/s41588-025-02118-0 · https://thessgac.com/ · https://github.com/AlexTISYoung/snipar · https://doi.org/10.5281/zenodo.14270274 | EUR (unified / Young et al. in White British); multi-ancestry robust estimator |
Direct genetic effects
UK Biobank family-based GWAS (Guan et al.)
PUBMED_LINK
DESCRIPTION
Family-based GWAS (FGWAS) summary statistics estimating direct genetic effects (DGEs) with unified, robust, Young et al. Mendelian-imputation, and sib-difference estimators implemented in snipar. Unified estimator adds singletons via linear parental imputation (largest DGE effective sample size in homogeneous samples); robust estimator avoids allele-frequency imputation bias under strong structure or admixture. UK Biobank application (n up to ~408k unified White British; ~52k robust with ≥1 genotyped first-degree relative).
URL
Main citation
Guan J, Tan T, Nehzati SM, Bennett M, ...&, Young AS. (2025) Family-based genome-wide association study designs for increased power and robustness. Nat Genet, 57 (4) 1044-1052. doi:10.1038/s41588-025-02118-0. PMID 40065166
DOI
10.1038/s41588-025-02118-0
RELATED_BIOBANK
MAIN ANCESTRY
EUR (unified / Young et al. in White British); multi-ancestry robust estimator